Kev faib tawm
Nroj Tsuag: Nws yog dav pom nyob rau hauv qia tawv, paj, nplooj, buds, noob, thiab txiv hmab txiv ntoo ntawm ntau cov nroj tsuag, feem ntau nyob rau hauv daim ntawv ntawm glycosides zoo li rutin, quercitrin, thiab hyperoside. Quercetin tuaj yeem tau los ntawm acid hydrolysis. Ntawm cov no, ntau dua muaj nyob rau hauv stems thiab nplooj ntawm buckwheat, seabuckthorn, hawthorn, thiab dos. Tsis tas li ntawd, ntau cov nroj tsuag tshuaj, xws li Sophora japonica, Platycodon grandiflorus nplooj, Galangal, Sophora flavescens, Mulberry Parasitic, Panax notoginseng, Ginkgo biloba, elderberry, thiab lwm yam, tag nrho cov muaj quercetin, nrog Sophora japonica muaj cov ntsiab lus ntawm kwv yees li 4%.
Cov teebmeem
Antioxidant: Nws yog ib qho muaj zog tshaj plaws antioxidants nyob rau hauv cov xwm, muaj peev xwm antioxidant 50 npaug ntawm cov vitamin E thiab 20 npaug ntawm cov vitamin C.
Hypolipidemic: Nws tuaj yeem cuam tshuam kev tawg ntawm cov cholesterol esters rau hauv cov roj (cholesterol) dawb, txo cov solubility ntawm cov cholesterol hauv cov tshuaj micelle, inhibit qhov nqus ntawm cov cholesterol los ntawm txoj hnyuv me, thiab yog li ua tiav lub hom phiaj ntawm kev txo qis lipids.
Hypoglycemic: Nws tuaj yeem cuam tshuam kev thauj cov piam thaj los ntawm kev thauj cov piam thaj, nrog rau kev ua haujlwm ntawm alpha amylase thiab alpha glucosidase, cuam tshuam kev zom zaub mov thiab nqus cov piam thaj.
Uric Acid Reduction: Los ntawm kev tsim hydrogen bonds nyob ib ncig ntawm lub molybdenum atom nyob rau hauv lub active centre ntawm xanthine oxidase (XO), nws inhibits lub substrate xanthine los ntawm kev nkag mus rau lub XO active chaw, inhibiting XO lub catalytic kev ua si ntawm xanthine thiab yog li txo uric acid ntau lawm.
Anticancer: Nws muaj cytotoxicity rau cov qog nqaij hlav cancer yam tsis muaj kev puas tsuaj rau cov hlwb noj qab haus huv thiab tuaj yeem siv los ua cov tshuaj tiv thaiv thiab kho mob rau ntau yam qog noj ntshav. Vim nws lipophilicity, nws tuaj yeem nkag mus rau hauv cov cell membrane yooj yim thiab siv cov tshuaj tiv thaiv kab mob los ntawm ntau txoj hauv kev, xws li tswj thiab inhibiting oncogene qhia, thaiv lub voj voog ntawm tes, inducing apoptosis, thiab inhibiting ntxeem tau thiab metastasis.
Neuroprotective: Nws tuaj yeem siv cov teebmeem neuroprotective los ntawm kev ncaj qha tshem tawm cov pa oxygen reactive (ROS) thiab inhibiting -amyloid (A) deposition, tau protein hyperphosphorylation, neurofibrillary tangles (NFTs), amyloid precursor proteins (APP), thiab lytic enzymes (BACE1) hauv paj hlwb. hlwb los ntawm ntau yam mechanisms.
Antithrombotic: Nws tuaj yeem cuam tshuam platelet aggregation, xaiv khi rau cov ntshav txhaws ntawm phab ntsa vascular, thiab tso cov tshuaj thrombolytic thiab vascular membrane tiv thaiv cov neeg nruab nrab los ntawm vascular endothelium los ntawm inhibiting platelet lipoxygenase thiab cyclooxygenase, yog li exerting antithrombotic.
Antiviral: Nws nthuav tawm cov haujlwm tiv thaiv kab mob tiv thaiv ntau yam kab mob, xws li herpes simplex virus type I, respiratory syncytial virus, rabies virus, type III parainfluenza virus, and the novel coronavirus. Nws cov tshuaj tiv thaiv kab mob cuam tshuam nrog kev khi rau cov kab mob kis kab mob thiab cuam tshuam nrog kev sib txuas ntawm cov kab mob nucleic acids.
Pharmacokinetics
Absorption: Hauv cov xwm txheej,quercetinFeem ntau muaj nyob rau hauv daim ntawv ntawm glucosides, thiab qhov nqus ntawm quercetin glucosides txawv nyob ntawm seb hom qab zib txuas. Nws cov glucuronide thiab sulfate derivatives tau yooj yim absorbed los ntawm tib neeg lub cev tshaj quercetin nws tus kheej. Glycosides tau zoo hydrolyzed los ntawm -glucosidase nyob rau hauv cov hnyuv me los tsim aglycones, uas tom qab ntawd absorbed thiab metabolized nyob rau hauv lub cev xws li cov hnyuv, plab, siab, thiab ob lub raum.
Kev tshem tawm: Kwv yees li 20% ntawm qhov ncauj quercetin yog nqus los ntawm lub plab zom mov, 30% yog metabolized, thiab 30% yog tawm hauv nws daim ntawv qub los ntawm quav. Cov quercetin absorbed sai sai nkag mus rau hauv cov kua tsib thiab zis nyob rau hauv daim ntawv ntawm glucuronide thiab sulfate esters nyob rau hauv 48 teev thiab raug tso tawm.
