Ib tsab xov xwm luam tawm hauv phau ntawv xov xwm RESEARCH. Cov kws tshawb fawb pom tias melatonin txo qis atrazine-vim lub raum tubular epithelial cell senescence thiab raum raug mob. Cov kws tshawb nrhiav pom tias melatonin ua lub luag haujlwm tseem ceeb hauv kev tswj hwm mitochondrial homeostasis.
upregulation ntawm kev qhia ntawm p53, p21, p16, thiab SASP yog lub cim ntawm cellular senescence. piv nrog cov tswj (Ctrl) pab pawg, pawg atrazine pom cov qib siab ntawm p53, phosphorylated p53 (p-p53), p21, thiab p16 proteins, thiab upregulated qhia ntawm SASP mRNA, thiab Parkin qib txo. Los ntawm kev ntxiv melatonin, qhov kev qhia ntawm cov cim kev laus yuav raug txo kom tsawg thiab atrazine-induced senescence ntawm lub raum tubular epithelial hlwb yuav txo tau. Tsis tas li ntawd, melatonin tshem tawm cov tsub zuj zuj ntawm reactive oxygen hom nyob rau hauv lub raum thiab inhibited lub raum oxidative kev nyuaj siab thiab mitochondrial puas los ntawm activating lub Sirtuin 3-superoxide dismutase 2 axis.
Melatonin, tseem hu ua 5-methoxy-N-acetyltryptamine, tau tshawb pom thiab cais tawm ntawm lub caj pas pineal xyoo 1958 los ntawm tus kws tshawb fawb Asmeskas Aaron Lerner.
Cov kws tshawb nrhiav pom tias melatonin tuaj yeem tswj tau qhov sib npaug thaum lub sijhawm ua rau lub plab. (Cov kws tshawb fawb tau xaiv matrix metalloproteinase (MMP) ua lub hom phiaj tseem ceeb ntawm melatonin. MMP plays lub luag haujlwm tseem ceeb hauv kev tswj hwm qhov sib npaug ntawm extracellular matrix degradation thiab kho cov ntaub so ntswg.) Yog li ntawd, melatonin tuaj yeem ua lub luag haujlwm tiv thaiv ntau yam kab mob hauv plab.
